Cannabinoids inhibit insulin secretion and cytosolic Ca2+ oscillation in islet β-cells via CB1 receptors

M Nakata, T Yada - Regulatory peptides, 2008 - Elsevier
Obesity is the main risk factor for the development of metabolic syndrome. Endogenous
cannabinoids act on the cannabinoid type 1 (CB1) receptor, a GPCR, and stimulate appetite
via central and peripheral actions, while blockade of CB1 receptor reduces body weight in
humans. In this study, we aimed to explore a role of the peripheral endocannabinoid system
in insulin secretion, which could be important in the metabolic effects of the cannabinoid-
CB1 system. We found that mRNA for CB1 receptor, but not CB2 receptor, was expressed in …