The cytosine DNA methyltransferase (MT) enzyme, which catalyzes DNA methylation at CpG
sites, is overexpressed at the mRNA level during the progressive stages of colon cancer.
This paper describes the adaption of a sensitive microassay for determining MT enzyme
activity during tumor progression in human colon and murine lung. MT activity was
progressively elevated in mucosa from familial adenomatosis polyposis patients, mucosa
adjacent to cancers, and in colonie adenocarcinomas when compared to colonie mucosa …