[HTML][HTML] Functional roles of the extracellular segments of the sodium channel α subunit in voltage-dependent gating and modulation by β1 subunits
Y Qu, JC Rogers, SF Chen, KA McCormick… - Journal of Biological …, 1999 - ASBMB
Voltage-gated sodium channels consist of a pore-forming α subunit associated with β1
subunits and, for brain sodium channels, β2 subunits. Although much is known about the
structure and function of the α subunit, there is little information on the functional role of the
16 extracellular loops. To search for potential functional activities of these extracellular
segments, chimeras were studied in which an individual extracellular loop of the rat heart
(rH1) α subunit was substituted for the corresponding segment of the rat brain type IIA (rIIA) α …
subunits and, for brain sodium channels, β2 subunits. Although much is known about the
structure and function of the α subunit, there is little information on the functional role of the
16 extracellular loops. To search for potential functional activities of these extracellular
segments, chimeras were studied in which an individual extracellular loop of the rat heart
(rH1) α subunit was substituted for the corresponding segment of the rat brain type IIA (rIIA) α …