[HTML][HTML] Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT
GR Crabtree - Cell, 1999 - cell.com
Cell, 1999•cell.com
A surprising and yet vexing outcome of the rapid progress made in understanding signal
transduction is the observation that while activation of specific receptors leads to highly
specific biologic responses, these receptors seem to use ubiquitous signaling intermediates.
One solution to this dilemma is that perhaps the specific signaling molecules are yet to be
discovered. This notion is consistent with the early analysis of EST collections indicating that
the mammalian genome encodes as many as 4,000 intracellular kinases and phosphatases …
transduction is the observation that while activation of specific receptors leads to highly
specific biologic responses, these receptors seem to use ubiquitous signaling intermediates.
One solution to this dilemma is that perhaps the specific signaling molecules are yet to be
discovered. This notion is consistent with the early analysis of EST collections indicating that
the mammalian genome encodes as many as 4,000 intracellular kinases and phosphatases …
A surprising and yet vexing outcome of the rapid progress made in understanding signal transduction is the observation that while activation of specific receptors leads to highly specific biologic responses, these receptors seem to use ubiquitous signaling intermediates. One solution to this dilemma is that perhaps the specific signaling molecules are yet to be discovered. This notion is consistent with the early analysis of EST collections indicating that the mammalian genome encodes as many as 4,000 intracellular kinases and phosphatases and as many as 10,000 transcription factors (
cell.com