Purkinje cells synthesize insulin-like growth factor I and express insulin-like growth factor I
receptors during their entire life. An additional source of insulin-like growth factor I for these
cells is provided by climbing fiber afferents originating in the inferior olive nucleus. Recently
we found that insulin-like growth factor I from the inferior olive is necessary for motor
learning processes probably involving Purkinje cell synaptic plasticity. We now studied
whether inferior olive insulin-like growth factor I influences the synaptic structure of Purkinje …