Interaction between krit1 and malcavernin: implications for the pathogenesis of cerebral cavernous malformations
J Zhang, D Rigamonti, HC Dietz, RE Clatterbuck - Neurosurgery, 2007 - journals.lww.com
OBJECTIVE Cerebral cavernous malformations (CCM) are a relatively common autosomal
dominant disorder leading to the formation of vascular malformations in the nervous system.
Mutations in krit1 and malcavernin, the proteins encoded by the genes at the CCM1 and
CCM2 loci, respectively, are responsible for the majority of CCMs. Similar to integrin
cytoplasmic domain-associated protein-1α, a known krit1 interactor, malcavernin is a
phosphotyrosine binding protein. We report here that krit1 also interacts with malcavernin …
dominant disorder leading to the formation of vascular malformations in the nervous system.
Mutations in krit1 and malcavernin, the proteins encoded by the genes at the CCM1 and
CCM2 loci, respectively, are responsible for the majority of CCMs. Similar to integrin
cytoplasmic domain-associated protein-1α, a known krit1 interactor, malcavernin is a
phosphotyrosine binding protein. We report here that krit1 also interacts with malcavernin …