Establishment of human IgE system in severe combined immunodeficient mice with peripheral blood mononuclear cells from asthmatic children
BL Chiang, CC Chou, HJ Ding, MS Huang… - Journal of allergy and …, 1995 - Elsevier
The frequency of allergic diseases, such as asthma, has increased rapidly during the past
decade; however, the exact mechanisms have not been established. In this study we tried to
establish an in vivo system to investigate immune regulation of allergic diseases by using
severe combined immunodeficient (SCID) mice. Peripheral blood mononuclear cells
isolated from asthmatic children or normal adults were injected into peritoneal cavities of
SCID mice. Human IgG, IgA, IgM, and IgE could be detected in SCID mice reconstituted with …
decade; however, the exact mechanisms have not been established. In this study we tried to
establish an in vivo system to investigate immune regulation of allergic diseases by using
severe combined immunodeficient (SCID) mice. Peripheral blood mononuclear cells
isolated from asthmatic children or normal adults were injected into peritoneal cavities of
SCID mice. Human IgG, IgA, IgM, and IgE could be detected in SCID mice reconstituted with …