Endotoxin-induced lethality in neonatal mice is counteracted by interleukin-10 (IL-10) and exacerbated by anti-IL-10
F Nicoletti, G Mancuso, FA Ciliberti… - Clinical Diagnostic …, 1997 - Am Soc Microbiol
F Nicoletti, G Mancuso, FA Ciliberti, C Beninati, M Carbone, S Franco, V Cusumano
Clinical Diagnostic Laboratory Immunology, 1997•Am Soc MicrobiolThe lethal effects occurring in neonatal (< 24-h-old) BALB/c mice after challenge with 25 mg
of lipopolysaccharide (LPS) per kg of body weight were significantly counteracted by
pretreatment with recombinant interleukin-10 (rIL-10; 25 or 50 ng/mouse). Concordantly,
blockage of endogenous IL-10 with the SXC1 monoclonal antibody increased LPS-induced
mortality. Both IL-10 and SXC1 modulated the release of tumor necrosis factor alpha (TNF-
alpha) so that, relative to controls, peak TNF-alpha values after LPS challenge were …
of lipopolysaccharide (LPS) per kg of body weight were significantly counteracted by
pretreatment with recombinant interleukin-10 (rIL-10; 25 or 50 ng/mouse). Concordantly,
blockage of endogenous IL-10 with the SXC1 monoclonal antibody increased LPS-induced
mortality. Both IL-10 and SXC1 modulated the release of tumor necrosis factor alpha (TNF-
alpha) so that, relative to controls, peak TNF-alpha values after LPS challenge were …
The lethal effects occurring in neonatal (<24-h-old) BALB/c mice after challenge with 25 mg of lipopolysaccharide (LPS) per kg of body weight were significantly counteracted by pretreatment with recombinant interleukin-10 (rIL-10; 25 or 50 ng/mouse). Concordantly, blockage of endogenous IL-10 with the SXC1 monoclonal antibody increased LPS-induced mortality. Both IL-10 and SXC1 modulated the release of tumor necrosis factor alpha (TNF-alpha) so that, relative to controls, peak TNF-alpha values after LPS challenge were decreased by rIL-10 and increased by anti-IL-10.
American Society for Microbiology