[HTML][HTML] Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic β-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein …
SJ Kim, K Winter, C Nian, M Tsuneoka, Y Koda… - Journal of Biological …, 2005 - ASBMB
The hormone glucose-dependent insulinotropic polypeptide (GIP) potently stimulates insulin
secretion and promotes β-cell proliferation and cell survival. In the present study we
identified Forkhead (Foxo1)-mediated suppression of the bax gene as a critical component
of the effects of GIP on cell survival. Treatment of INS-1 (832/13) β-cells with GIP resulted in
concentration-dependent activation of the phosphatidylinositol 3-kinase (PI3K)/protein
kinase B (PKB)/Foxo1 signaling module. In parallel studies, GIP decreased bax promoter …
secretion and promotes β-cell proliferation and cell survival. In the present study we
identified Forkhead (Foxo1)-mediated suppression of the bax gene as a critical component
of the effects of GIP on cell survival. Treatment of INS-1 (832/13) β-cells with GIP resulted in
concentration-dependent activation of the phosphatidylinositol 3-kinase (PI3K)/protein
kinase B (PKB)/Foxo1 signaling module. In parallel studies, GIP decreased bax promoter …