[HTML][HTML] Surface expression and endocytosis of the human cytomegalovirus-encoded chemokine receptor US28 is regulated by agonist-independent phosphorylation
T Mokros, A Rehm, J Droese, M Oppermann… - Journal of Biological …, 2002 - ASBMB
Human cytomegalovirus encodes the G protein-coupled chemokine receptor homologue
US28 that binds several CC chemokines and sequesters extracellular chemokines from the
environment of infected cells. Mechanistically, it has been shown that US28 undergoes rapid
constitutive receptor endocytosis and recycling. Monoclonal antibodies were raised that
allowed the characterization of a ligand-independent phosphorylation and low surface
expression of the US28 receptor in transiently transfected HEK293A cells. Phosphoamino …
US28 that binds several CC chemokines and sequesters extracellular chemokines from the
environment of infected cells. Mechanistically, it has been shown that US28 undergoes rapid
constitutive receptor endocytosis and recycling. Monoclonal antibodies were raised that
allowed the characterization of a ligand-independent phosphorylation and low surface
expression of the US28 receptor in transiently transfected HEK293A cells. Phosphoamino …