Isogenic mutant human cells: A new tool for personalized cancer medicine Page 1 Cell Cycle
9:1, 20-21; January 1, 2010; © 2010 Landes Bioscience CeLL CyCLe Features 20 Cell Cycle
Volume 9 Issue 1 Features Recent large sequencing efforts of the human cancer genome
have unveiled a highly heterogeneous pattern of mutated genes even among tumors of the
same tissue origin. In the majority of cases, the function of these mutated alleles is not well
characterized, and future studies will increasingly have to rely on cell-based models to assess …