Mitochondria, oxygen free radicals, disease and ageing
S Raha, BH Robinson - Trends in biochemical sciences, 2000 - cell.com
S Raha, BH Robinson
Trends in biochemical sciences, 2000•cell.comSuperoxide is generated by the mitochondrial respiratory chain. The transformation of this
superoxide into hydrogen peroxide and, under certain conditions, then into hydroxyl radicals
is important in diseases where respiratory chain function is abnormal or where superoxide
dismutase function is altered, as in amyotrophic lateral sclerosis. In additon, these reactive
oxygen species can influence the ageing process through mechanisms involving
mutagenesis of mtDNA or increased rates of shortening of telomeric DNA.
superoxide into hydrogen peroxide and, under certain conditions, then into hydroxyl radicals
is important in diseases where respiratory chain function is abnormal or where superoxide
dismutase function is altered, as in amyotrophic lateral sclerosis. In additon, these reactive
oxygen species can influence the ageing process through mechanisms involving
mutagenesis of mtDNA or increased rates of shortening of telomeric DNA.
Abstract
Superoxide is generated by the mitochondrial respiratory chain. The transformation of this superoxide into hydrogen peroxide and, under certain conditions, then into hydroxyl radicals is important in diseases where respiratory chain function is abnormal or where superoxide dismutase function is altered, as in amyotrophic lateral sclerosis. In additon, these reactive oxygen species can influence the ageing process through mechanisms involving mutagenesis of mtDNA or increased rates of shortening of telomeric DNA.
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