Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma
Z Jiang, X Li, J Hu, W Zhou, Y Jiang, G Li, D Lu - Neuroscience research, 2006 - Elsevier
LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle, but
their methylation statuses are still unknown in human astrocytoma. Here, we found that the
promoter hypermethylation frequencies of LATS1 and LATS1 were 63.66%(56/88) and
71.5%(63/88) in 88 astrocytomas by methylation-specific PCR. But no methylation of LATS1
and LATS2 promoter was detected in the 10 normal brain tissues. There was an increased
methylation frequency of LATS1 and LATS2 with the malignant development of astrcytoma …
their methylation statuses are still unknown in human astrocytoma. Here, we found that the
promoter hypermethylation frequencies of LATS1 and LATS1 were 63.66%(56/88) and
71.5%(63/88) in 88 astrocytomas by methylation-specific PCR. But no methylation of LATS1
and LATS2 promoter was detected in the 10 normal brain tissues. There was an increased
methylation frequency of LATS1 and LATS2 with the malignant development of astrcytoma …