[HTML][HTML] Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1α and is not induced by hypoxia or HIF
The hypoxia-inducible factor (HIF) is a key player in a transcriptional pathway that controls
the hypoxic response of mammalian cells. Post-translational modification of the α subunit of
HIF determines its half-life and activity. Among the multiple reported modifications,
acetylation, by an acetyltransferase termed arrest-defective-1 protein (ARD1), has been
reported to decrease HIF-1α stability and therefore impact on hypoxic gene expression. In
contrast, we report that both overexpression and silencing of ARD1 had no impact on the …
the hypoxic response of mammalian cells. Post-translational modification of the α subunit of
HIF determines its half-life and activity. Among the multiple reported modifications,
acetylation, by an acetyltransferase termed arrest-defective-1 protein (ARD1), has been
reported to decrease HIF-1α stability and therefore impact on hypoxic gene expression. In
contrast, we report that both overexpression and silencing of ARD1 had no impact on the …