p94, a muscle-specific member of calpain family, is unique in that it undergoes rapid and
exhaustive autolysis with a half-life of less than 1 h resulting in its disappearance from
muscle. Recently, p94 was shown to be responsible for limb girdle muscular dystrophy type
2A. To elucidate the muscular proteolytic system mediated by p94 and to solve the mystery
of its unusually rapid autolysis, we searched for p94-binding proteins by the two-hybrid
system. Although calpain small subunit plays a crucial role for regulation of ubiquitous …