Inhibition of fructose-1, 6-bisphosphatase by fructose 2, 6-biphosphate.
E Van Schaftingen, HG Hers - Proceedings of the National …, 1981 - National Acad Sciences
E Van Schaftingen, HG Hers
Proceedings of the National Academy of Sciences, 1981•National Acad SciencesFructose 2, 6-bisphosphate, a known powerful stimulator of phosphofructokinase [Van
Schaftingen, E., Hue, L. & Hers, H.-G.(1980) Biochem. J. 192, 897-901] was found to inhibit,
at micromolar concentrations, liver and muscle fructose-1, 6-biphosphate (D-fructose-1, 6-
bisphosphate 1-phosphohydrolase, EC 3.1. 3.11). The main characteristics of this inhibition
are that (i) it is much stronger at low than at high substrate concentrations,(ii) it changes the
substrate saturation curve from almost hyperbolic to sigmoidal, and (iii) it is synergistic with …
Schaftingen, E., Hue, L. & Hers, H.-G.(1980) Biochem. J. 192, 897-901] was found to inhibit,
at micromolar concentrations, liver and muscle fructose-1, 6-biphosphate (D-fructose-1, 6-
bisphosphate 1-phosphohydrolase, EC 3.1. 3.11). The main characteristics of this inhibition
are that (i) it is much stronger at low than at high substrate concentrations,(ii) it changes the
substrate saturation curve from almost hyperbolic to sigmoidal, and (iii) it is synergistic with …
Fructose 2,6-bisphosphate, a known powerful stimulator of phosphofructokinase [Van Schaftingen, E., Hue, L. & Hers, H.-G. (1980) Biochem. J. 192, 897-901] was found to inhibit, at micromolar concentrations, liver and muscle fructose-1,6-biphosphate (D-fructose-1,6-bisphosphate 1-phosphohydrolase, EC 3.1.3.11). The main characteristics of this inhibition are that (i) it is much stronger at low than at high substrate concentrations, (ii) it changes the substrate saturation curve from almost hyperbolic to sigmoidal, and (iii) it is synergistic with the inhibition by AMP. This inhibition may play an important role in the stimulation of gluconeogenesis by glucagon, because this hormone is known to decrease the concentration of fructose 2,6-bisphosphate in the liver [Van Schaftingen, E., Hue, L. & Hers, H.-G. (1980) Biochem. J. 192, 887-895].
National Acad Sciences