[HTML][HTML] Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B
H He, Y Dang, F Dai, Z Guo, J Wu, X She, Y Pei… - Journal of Biological …, 2003 - ASBMB
The molecular machinery required for autophagy is highly conserved in all eukaryotes as
seen by the high degree of conservation of proteins involved in the formation of the
autophagosome membranes. Recently, both yeast Apg8p and its rat homologue Map1lc3
were identified as essential constituents of autophagosome membrane as a processed form.
In addition, both the yeast and human proteins exist in two modified forms produced by a
series of post-translational modifications including a critical C-terminal cleavage after a …
seen by the high degree of conservation of proteins involved in the formation of the
autophagosome membranes. Recently, both yeast Apg8p and its rat homologue Map1lc3
were identified as essential constituents of autophagosome membrane as a processed form.
In addition, both the yeast and human proteins exist in two modified forms produced by a
series of post-translational modifications including a critical C-terminal cleavage after a …