Aminoglycosides are bactericidal aminoglycosidic aminocyclitols. They are cost effective
and therefore widely used, however ototoxicity is a prominent dose-limiting side effect.
Aminoglycoside induced ototoxicity leads to permanent bilaterally severe, high-frequency
sensorineural hearing loss and temporary vestibular hypofunction. The permanent hearing
loss is accompanied by degeneration of hair cells and neurons in the cochlea. An iron–
aminoglycoside complex is believed to potentiate ROS-induced cellular degeneration in the …