[HTML][HTML] A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L
J Hemelaar, VS Lelyveld, BM Kessler… - Journal of biological …, 2003 - ASBMB
Apg8 is a ubiquitin-like protein involved in autophagy in yeast. Apg8 is covalently but
transiently attached to membrane lipids through the actions of activating, conjugating, and
processing/deconjugating enzymes. The mammalian Apg8 homologues GATE-16,
GARARAP, and MAP1-LC3 have been implicated in intra-Golgi transport, receptor sorting,
and autophagy, respectively. All are served by a single set of activating and conjugating
enzymes. Here we identify a novel mammalian Apg8 homologue, which we name Apg8L …
transiently attached to membrane lipids through the actions of activating, conjugating, and
processing/deconjugating enzymes. The mammalian Apg8 homologues GATE-16,
GARARAP, and MAP1-LC3 have been implicated in intra-Golgi transport, receptor sorting,
and autophagy, respectively. All are served by a single set of activating and conjugating
enzymes. Here we identify a novel mammalian Apg8 homologue, which we name Apg8L …