[HTML][HTML] Missing pieces in the NF-κB puzzle

S Ghosh, M Karin - cell, 2002 - cell.com
cell, 2002cell.com
The regulation of the transcription factor NF-κB activity occurs at several levels including
controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A
critical component in NF-κB regulation is the IκB kinase (IKK) complex. This review is
focused on recent progress as well as unanswered questions regarding the regulation and
function of NF-κB and IKK.
Abstract
The regulation of the transcription factor NF-κB activity occurs at several levels including controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A critical component in NF-κB regulation is the IκB kinase (IKK) complex. This review is focused on recent progress as well as unanswered questions regarding the regulation and function of NF-κB and IKK.
cell.com