[HTML][HTML] Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU. 1
M Matsumoto, M Kogawa, S Wada… - Journal of Biological …, 2004 - ASBMB
The receptor activator of NF-κB ligand (RANKL) induces various osteoclast-specific marker
genes during osteoclast differentiation mediated by mitogen-activated protein (MAP) kinase
cascades. However, the results of transcriptional programming of an osteoclast-specific
cathepsin K gene are inconclusive. Here we report the regulatory mechanisms of RANKL-
induced cathepsin K gene expression during osteoclastogenesis in a p38 MAP kinase-
dependent manner. The reporter gene analysis with sequential 5′-deletion constructs of …
genes during osteoclast differentiation mediated by mitogen-activated protein (MAP) kinase
cascades. However, the results of transcriptional programming of an osteoclast-specific
cathepsin K gene are inconclusive. Here we report the regulatory mechanisms of RANKL-
induced cathepsin K gene expression during osteoclastogenesis in a p38 MAP kinase-
dependent manner. The reporter gene analysis with sequential 5′-deletion constructs of …