Primary isolation of the bovine spongiform encephalopathy agent in mice: agent definition based on a review of 150 transmissions
R Green, C Horrocks, A Wilkinson, SAC Hawkins… - Journal of comparative …, 2005 - Elsevier
In the epizootic of bovine spongiform encephalopathy (BSE) in Great Britain, the cattle in
which a positive diagnosis was made numbered almost 180 000, but strain characterization
was performed on only a very small sample of these cases. This report describes the results
of BSE transmission to Prnpa mice from 150 transmission experiments at the Veterinary
Laboratories Agency (VLA) over the last decade. These data, derived from a large sample of
BSE-affected cattle, confirmed previous reports that show no evidence for diversity in BSE …
which a positive diagnosis was made numbered almost 180 000, but strain characterization
was performed on only a very small sample of these cases. This report describes the results
of BSE transmission to Prnpa mice from 150 transmission experiments at the Veterinary
Laboratories Agency (VLA) over the last decade. These data, derived from a large sample of
BSE-affected cattle, confirmed previous reports that show no evidence for diversity in BSE …