[HTML][HTML] Interleukin-8-mediated heterologous receptor internalization provides resistance to HIV-1 infectivity: role of signal strength and receptor desensitization
RM Richardson, K Tokunaga, R Marjoram… - Journal of Biological …, 2003 - ASBMB
Human immunodeficiency virus type 1 (HIV-1) entry into CD4+ cells requires the chemokine
receptors CCR5 or CXCR4 as co-fusion receptors. We have previously demonstrated that
chemokine receptors are capable of cross-regulating the functions of each other and, thus,
affecting cellular responsiveness at the site of infection. To investigate the effects of
chemokine receptor cross-regulation in HIV-1 infection, monocytes and MAGIC5 and rat
basophilic leukemia (RBL-2H3) cell lines co-expressing the interleukin-8 (IL-8 or CXCL8) …
receptors CCR5 or CXCR4 as co-fusion receptors. We have previously demonstrated that
chemokine receptors are capable of cross-regulating the functions of each other and, thus,
affecting cellular responsiveness at the site of infection. To investigate the effects of
chemokine receptor cross-regulation in HIV-1 infection, monocytes and MAGIC5 and rat
basophilic leukemia (RBL-2H3) cell lines co-expressing the interleukin-8 (IL-8 or CXCL8) …