Relationship between chromatin structure, DNA damage and repair following X-irradiation of human lymphocytes
P Mosesso, F Palitti, G Pepe, J Piñero… - … /Genetic Toxicology and …, 2010 - Elsevier
Earlier studies using the technique of premature chromosome condensation (PCC) have
shown that in human lymphocytes, exchange type of aberrations are formed immediately
following low doses (< 2Gy) of X-rays, whereas at higher doses these aberrations increase
with the duration of recovery. This reflects the relative roles of slow and fast repair in the
formation of exchange aberrations. The underlying basis for slow and fast repairing
components of the DNA repair may be related to differential localization of the initial damage …
shown that in human lymphocytes, exchange type of aberrations are formed immediately
following low doses (< 2Gy) of X-rays, whereas at higher doses these aberrations increase
with the duration of recovery. This reflects the relative roles of slow and fast repair in the
formation of exchange aberrations. The underlying basis for slow and fast repairing
components of the DNA repair may be related to differential localization of the initial damage …