Antiproliferative effects of EGFR tyrosine kinase inhibition and radiation-induced genotoxic injury are attenuated by adhesion to fibronectin

I Eke, V Sandfort, A Mischkus, M Baumann… - Radiotherapy and …, 2006 - Elsevier
BACKGROUND AND PURPOSE: Integrin-linked kinase (ILK) functions in cooperative
integrin-growth factor receptor-mediated signaling to control cell survival and proliferation.
The effect of tyrosine kinase (tk) inhibition of the epidermal growth factor receptor (EGFR) on
radiation survival and growth was evaluated in human FaDu squamous cell carcinoma cells
expressing different forms of ILK. MATERIAL AND METHODS: ILK-wild-type (wk) and-
hyperactive kinase (hk) transfected cells were grown on fibronectin (Fn) under serum …