[HTML][HTML] Integrin cross-talk in endothelial cells is regulated by protein kinase A and protein phosphatase 1
AM Gonzalez, J Claiborne, JCR Jones - Journal of biological chemistry, 2008 - ASBMB
In endothelial cells (ECs) β1 integrin function-blocking antibodies inhibit αvβ3 integrin-
mediated adhesion to a recombinant α4-laminin fragment (rα4LN fragment). β1 integrin
sequestration of talin is not the mechanism by which β1 integrin modulates αvβ3 integrin
ligand binding. Rather, treatment of the ECs with β1 integrin function-blocking antibodies
enhances cAMP-dependent protein kinase (PKA) activity and increases β3 integrin serine
phosphorylation. The PKA inhibitor H-89 abrogates the effect of β1 integrin function-blocking …
mediated adhesion to a recombinant α4-laminin fragment (rα4LN fragment). β1 integrin
sequestration of talin is not the mechanism by which β1 integrin modulates αvβ3 integrin
ligand binding. Rather, treatment of the ECs with β1 integrin function-blocking antibodies
enhances cAMP-dependent protein kinase (PKA) activity and increases β3 integrin serine
phosphorylation. The PKA inhibitor H-89 abrogates the effect of β1 integrin function-blocking …