[HTML][HTML] A novel function of syndecan-2, suppression of matrix metalloproteinase-2 activation, which causes suppression of metastasis
S Munesue, Y Yoshitomi, Y Kusano, Y Koyama… - Journal of biological …, 2007 - ASBMB
The syndecans comprise a family of cell surface heparan sulfate proteoglycans exhibiting
complex biological functions involving the interaction of heparan sulfate side chains with a
variety of soluble and insoluble heparin-binding extracellular ligands. Here we demonstrate
an inverse correlation between the expression level of syndecan-2 and the metastatic
potential of three clones derived from Lewis lung carcinoma 3LL. This correlation was
proved to be a causal relationship, because transfection of syndecan-2 into the higher …
complex biological functions involving the interaction of heparan sulfate side chains with a
variety of soluble and insoluble heparin-binding extracellular ligands. Here we demonstrate
an inverse correlation between the expression level of syndecan-2 and the metastatic
potential of three clones derived from Lewis lung carcinoma 3LL. This correlation was
proved to be a causal relationship, because transfection of syndecan-2 into the higher …