CD8 T cell dysfunction during chronic viral infection
H Shin, EJ Wherry - Current opinion in immunology, 2007 - Elsevier
H Shin, EJ Wherry
Current opinion in immunology, 2007•ElsevierClearance of primary infection often leads to the development of highly functional memory T
cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections
can result in T cell dysfunction and poor pathogen control. In this review, we will discuss
recent work that highlights two main types of T cell dysfunction during chronic infection:
exhaustion of effector functions and altered memory T cell development.
cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections
can result in T cell dysfunction and poor pathogen control. In this review, we will discuss
recent work that highlights two main types of T cell dysfunction during chronic infection:
exhaustion of effector functions and altered memory T cell development.
Clearance of primary infection often leads to the development of highly functional memory T cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections can result in T cell dysfunction and poor pathogen control. In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development.
Elsevier