[HTML][HTML] Inactivation of the inhibitory κB protein kinase/nuclear factor κB pathway by Par-4 expression potentiates tumor necrosis factor α-induced apoptosis
MT Diaz-Meco, MJ Lallena, A Monjas, S Frutos… - Journal of Biological …, 1999 - ASBMB
Par-4 is a novel protein identified in cells undergoing apoptosis. The ability of Par-4 to
promote apoptotic cell death is dependent on the binding and inactivation of the atypical
protein kinases C (PKCs). This subfamily of kinases has been reported to control nuclear
factor κB (NF-κB) through the regulation of the IκB kinase activity. NF-κB activation by tumor
necrosis factor α (TNFα) provides a survival signal that impairs the TNFα-induced apoptotic
response. We show here that expression of Par-4 inhibits the TNFα-induced nuclear …
promote apoptotic cell death is dependent on the binding and inactivation of the atypical
protein kinases C (PKCs). This subfamily of kinases has been reported to control nuclear
factor κB (NF-κB) through the regulation of the IκB kinase activity. NF-κB activation by tumor
necrosis factor α (TNFα) provides a survival signal that impairs the TNFα-induced apoptotic
response. We show here that expression of Par-4 inhibits the TNFα-induced nuclear …