[HTML][HTML] Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of endothelial nitric-oxide synthase
M Kondo, R Shibata, R Miura, M Shimano… - Journal of biological …, 2009 - ASBMB
Caloric restriction (CR) can extend longevity and modulate the features of obesity-related
metabolic and vascular diseases. However, the functional roles of CR in regulation of
revascularization in response to ischemia have not been examined. Here we investigated
whether CR modulates vascular response by employing a murine hindlimb ischemia model.
Wild-type (WT) mice were randomly divided into two groups that were fed either ad libitum
(AL) or CR (65% of the diet consumption of AL). Four weeks later, mice were subjected to …
metabolic and vascular diseases. However, the functional roles of CR in regulation of
revascularization in response to ischemia have not been examined. Here we investigated
whether CR modulates vascular response by employing a murine hindlimb ischemia model.
Wild-type (WT) mice were randomly divided into two groups that were fed either ad libitum
(AL) or CR (65% of the diet consumption of AL). Four weeks later, mice were subjected to …