Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data

RS Vasan, NL Glazer, JF Felix, W Lieb, PS Wild… - Jama, 2009 - jamanetwork.com
Context Echocardiographic measures of left ventricular (LV) structure and function are
heritable phenotypes of cardiovascular disease. Objective To identify common genetic
variants associated with cardiac structure and function by conducting a meta-analysis of
genome-wide association data in 5 population-based cohort studies (stage 1) with
replication (stage 2) in 2 other community-based samples. Design, Setting, and Participants
Within each of 5 community-based cohorts comprising the EchoGen consortium (stage 1; n …