Scrapie in mice: agent-strain differences in the distribution and intensity of grey matter vacuolation
H Fraser, AG Dickinson - Journal of comparative pathology, 1973 - Elsevier
Five strains of scrapie agent were used as intracerebral inocula for 2 inbred mouse strains,
C57BL and VM, and their F 1 cross. The degree of vacuolation in specified regions of the
brain, and the relative distribution of this damage in 9 regions represented as a “lesion
profile”, was different for each agent. Any of the 5 scrapie agents could be distinguished from
the others with a very high degree of reliability solely on the basis of these histological
parameters, using either strain of mouse. The lesion profile was unaffected by the dose of …
C57BL and VM, and their F 1 cross. The degree of vacuolation in specified regions of the
brain, and the relative distribution of this damage in 9 regions represented as a “lesion
profile”, was different for each agent. Any of the 5 scrapie agents could be distinguished from
the others with a very high degree of reliability solely on the basis of these histological
parameters, using either strain of mouse. The lesion profile was unaffected by the dose of …