NF-κB in cancer: from innocent bystander to major culprit
M Karin, Y Cao, FR Greten, ZW Li - Nature reviews cancer, 2002 - nature.com
M Karin, Y Cao, FR Greten, ZW Li
Nature reviews cancer, 2002•nature.comNuclear factor of κB (NF-κB) is a sequence-specific transcription factor that is known to be
involved in the inflammatory and innate immune responses. Although the importance of NF-
κB in immunity is undisputed, recent evidence indicates that NF-κB and the signalling
pathways that are involved in its activation are also important for tumour development. NF-
κB should therefore receive as much attention from cancer researchers as it has already
from immunologists.
involved in the inflammatory and innate immune responses. Although the importance of NF-
κB in immunity is undisputed, recent evidence indicates that NF-κB and the signalling
pathways that are involved in its activation are also important for tumour development. NF-
κB should therefore receive as much attention from cancer researchers as it has already
from immunologists.
Abstract
Nuclear factor of κB (NF-κB) is a sequence-specific transcription factor that is known to be involved in the inflammatory and innate immune responses. Although the importance of NF-κB in immunity is undisputed, recent evidence indicates that NF-κB and the signalling pathways that are involved in its activation are also important for tumour development. NF-κB should therefore receive as much attention from cancer researchers as it has already from immunologists.
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