Transferrin receptor-1 and 2 expression in chronic lymphocytic leukemia
Transferrin receptor (TfR)-1 and 2 mRNA and CD71 (TfR1) expression was analyzed in 118
CLL patients. Ninety-five out of 109 analyzed cases expressed CD71, mostly at a high level;
60% of CD71 (+) cases were IGH-mutated. All samples were TfR1 mRNA (+); TfR2-
alpha/beta mRNA was detected in, respectively, 52/102 and 100/109 cases. Competitive RT-
PCR showed widely divergent levels of TfR1 mRNA in cases with high CD71 expression,
alluding to postrtanscriptional control of TfR1 expression in CLL. The almost uniformly high …
CLL patients. Ninety-five out of 109 analyzed cases expressed CD71, mostly at a high level;
60% of CD71 (+) cases were IGH-mutated. All samples were TfR1 mRNA (+); TfR2-
alpha/beta mRNA was detected in, respectively, 52/102 and 100/109 cases. Competitive RT-
PCR showed widely divergent levels of TfR1 mRNA in cases with high CD71 expression,
alluding to postrtanscriptional control of TfR1 expression in CLL. The almost uniformly high …