The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells
DR Richardson, P Ponka - Biochimica Et Biophysica Acta (BBA)-Reviews …, 1997 - Elsevier
Virtually all living cells possess an absolute re-Ž. quirement for iron Fe, and it has been
suggested that reactions catalyzed by Fe may have constituted a wx first step in the origin of
life 1, 2. Approximately 5% of the earth's crust is composed of Fe, and this great abundance
coupled with the fact that the metal has two readily interconvertible redox states, has led to
its evolutionary selection for an astonishing array of biological reactions. Iron exerts its
function either in the form of numerous non-heme Fe-containing proteins or as the Fe …
suggested that reactions catalyzed by Fe may have constituted a wx first step in the origin of
life 1, 2. Approximately 5% of the earth's crust is composed of Fe, and this great abundance
coupled with the fact that the metal has two readily interconvertible redox states, has led to
its evolutionary selection for an astonishing array of biological reactions. Iron exerts its
function either in the form of numerous non-heme Fe-containing proteins or as the Fe …