[HTML][HTML] Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective …
JA Morris, AJ Dorner, CA Edwards… - Journal of Biological …, 1997 - ASBMB
BiP/GRP78 is a lumenal stress protein of the endoplasmic reticulum (ER) that interacts with
polypeptide folding intermediates transiting the secretory compartment. We have studied the
secretion and the stress response in Chinese hamster ovary (CHO) cells that overexpress
either wild-type immunoglobulin binding protein (BiP) or a BiP deletion molecule (residues
175-201) that can bind peptides and ATP but is defective in ATP hydrolysis and concomitant
peptide release. Overexpressed wild-type BiP was localized to the ER and unique vesicles …
polypeptide folding intermediates transiting the secretory compartment. We have studied the
secretion and the stress response in Chinese hamster ovary (CHO) cells that overexpress
either wild-type immunoglobulin binding protein (BiP) or a BiP deletion molecule (residues
175-201) that can bind peptides and ATP but is defective in ATP hydrolysis and concomitant
peptide release. Overexpressed wild-type BiP was localized to the ER and unique vesicles …