Negative regulation of cytokine signaling and inflammatory diseases
K Inagaki-Ohara, T Hanada, A Yoshimura - Current opinion in …, 2003 - Elsevier
Immune and inflammatory systems are controlled by multiple cytokines, including
interleukins and interferons. These cytokines exert their biological functions through Janus
tyrosine kinases and signal transducer and activators of transcription (STATs). The cytokine-
inducible SH2 proteins (CIS) and suppressors of cytokine signaling (SOCS) are a family of
intracellular proteins, several of which have emerged as key physiological regulators of
cytokine responses, including those that regulate the inflammatory system. Several recent …
interleukins and interferons. These cytokines exert their biological functions through Janus
tyrosine kinases and signal transducer and activators of transcription (STATs). The cytokine-
inducible SH2 proteins (CIS) and suppressors of cytokine signaling (SOCS) are a family of
intracellular proteins, several of which have emerged as key physiological regulators of
cytokine responses, including those that regulate the inflammatory system. Several recent …