Hypothalamic thyroid hormone feedback in health and disease
E Fliers, A Alkemade, WM Wiersinga… - Progress in brain research, 2006 - Elsevier
The role of the human hypothalamus in the neuroendocrine response to illness has only
recently begun to be explored. Extensive changes in the hypothalamus–pituitary–thyroid
(HPT) axis occur within the framework of critical illness. The best-documented change in the
HPT axis is a decrease in serum concentrations of the biologically active thyroid hormone
triiodothyronine (T3). From studies in post-mortem human hypothalamus it appeared that
low serum T3 and thyrotropin (TSH) during illness (nonthyroidal illness, NTI) are paralleled …
recently begun to be explored. Extensive changes in the hypothalamus–pituitary–thyroid
(HPT) axis occur within the framework of critical illness. The best-documented change in the
HPT axis is a decrease in serum concentrations of the biologically active thyroid hormone
triiodothyronine (T3). From studies in post-mortem human hypothalamus it appeared that
low serum T3 and thyrotropin (TSH) during illness (nonthyroidal illness, NTI) are paralleled …