[HTML][HTML] Expression of CTL associated transcripts precedes the development of tubulitis in T‐cell mediated kidney graft rejection
E Gunilla, M Anette, V Ramassar, LF Zhu… - American journal of …, 2005 - Elsevier
The usual phenotype of clinical kidney allograft rejection is infiltration by lymphocytes and
macrophages and evolution of histologic Banff lesions, particularly tubulitis, which indicate
parenchymal injury. Using Affymetrix microarrays, we evaluated the relationship between
the evolution of pathologic lesions and the transcriptome. We studied CBA/J into C57Bl/6
mouse kidney allografts in which one host kidney is left in place to permit observation of
lesion development. Histology was dominated by early infiltration by mononuclear cells from …
macrophages and evolution of histologic Banff lesions, particularly tubulitis, which indicate
parenchymal injury. Using Affymetrix microarrays, we evaluated the relationship between
the evolution of pathologic lesions and the transcriptome. We studied CBA/J into C57Bl/6
mouse kidney allografts in which one host kidney is left in place to permit observation of
lesion development. Histology was dominated by early infiltration by mononuclear cells from …