Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins
S Lim, C Sala, J Yoon, S Park, S Kuroda… - Molecular and Cellular …, 2001 - Elsevier
The Shank family of proteins (also termed CortBP, ProSAP, or Synamon) is highly enriched
in the postsynaptic density (PSD) of excitatory synapses in brain. Shank contains multiple
domains for protein–protein interactions, including ankyrin repeats, SH3 domain, PDZ
domain, SAM domain, and an extensive proline-rich region. We have identified a novel
protein, termed Sharpin, that directly interacts with the ankyrin repeats of Shank. Sharpin is
enriched in the PSD and forms a complex with Shank in heterologous cells and brain …
in the postsynaptic density (PSD) of excitatory synapses in brain. Shank contains multiple
domains for protein–protein interactions, including ankyrin repeats, SH3 domain, PDZ
domain, SAM domain, and an extensive proline-rich region. We have identified a novel
protein, termed Sharpin, that directly interacts with the ankyrin repeats of Shank. Sharpin is
enriched in the PSD and forms a complex with Shank in heterologous cells and brain …