[HTML][HTML] NF-κ B promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4
G Helbig, KW Christopherson, P Bhat-Nakshatri… - Journal of biological …, 2003 - ASBMB
Metastasis of cancer cells is a complex process involving multiple steps including invasion,
angiogenesis, and trafficking of cancer cells through blood vessels, extravasations, organ-
specific homing, and growth. While matrix metalloproteinases, urokinase-type plasminogen
activator, and cytokines play a major role in invasion and angiogenesis, chemokines such
as stromal derived factor-1α (SDF-1α) and their receptors such as CXCR4 are thought to
play a critical role in motility, homing, and proliferation of cancer cells at specific metastatic …
angiogenesis, and trafficking of cancer cells through blood vessels, extravasations, organ-
specific homing, and growth. While matrix metalloproteinases, urokinase-type plasminogen
activator, and cytokines play a major role in invasion and angiogenesis, chemokines such
as stromal derived factor-1α (SDF-1α) and their receptors such as CXCR4 are thought to
play a critical role in motility, homing, and proliferation of cancer cells at specific metastatic …