[HTML][HTML] The fourth blade within the β-propeller is involved specifically in C3bi recognition by integrin αMβ2

Y Li, L Zhang - Journal of Biological Chemistry, 2003 - ASBMB
Interactions between the complement degradation product C3bi and leukocyte integrin α M
β 2 are critical to phagocytosis of opsonized particles in host defense against foreign
pathogens and certain malignant cells. Previous studies have mapped critical residues for
C3bi binding to the I-domains of the α M and the β 2 subunits. However, the role of the α M β-
propeller in ligand binding remains less well defined, and the functional residues are still
unknown. In the present study, we studied the function of the α M β-propeller in specific …