The need for tolerance in pediatric organ transplantation
AZ Traum, T Kawai, JP Vacanti, DH Sachs… - …, 2008 - publications.aap.org
TRANSPLANTATION IS THE preferred therapy for pediatric end stage diseases of a variety
of solid organs. Unfortunately, however, transplantation does not restore patients to a normal
life, because they are left on lifelong immunosuppression with its associated complications.
In addition, even when immunosuppression is properly administered, there is progressive
loss of allograft function through a process called “chronic allograft dysfunction” that leads to
loss of 4% of transplanted organs per year. Exciting new findings in adult transplant patients …
of solid organs. Unfortunately, however, transplantation does not restore patients to a normal
life, because they are left on lifelong immunosuppression with its associated complications.
In addition, even when immunosuppression is properly administered, there is progressive
loss of allograft function through a process called “chronic allograft dysfunction” that leads to
loss of 4% of transplanted organs per year. Exciting new findings in adult transplant patients …