[HTML][HTML] Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice
K Ishiguro, K Kadomatsu, T Kojima… - Journal of Biological …, 2001 - ASBMB
Syndecan-4 is a transmembrane heparan sulfate proteoglycan belonging to the syndecan
family. Following intraperitoneal injection of lipopolysaccharide (LPS), syndecan-4-deficient
mice exhibited high mortality compared with wild-type controls. Severe endotoxin shock was
observed in the deficient mice: systolic blood pressure and left ventricular fractional
shortening were lower in the deficient mice than in the wild-type controls 9 h after LPS
injection. Although histological examinations revealed no apparent differences between two …
family. Following intraperitoneal injection of lipopolysaccharide (LPS), syndecan-4-deficient
mice exhibited high mortality compared with wild-type controls. Severe endotoxin shock was
observed in the deficient mice: systolic blood pressure and left ventricular fractional
shortening were lower in the deficient mice than in the wild-type controls 9 h after LPS
injection. Although histological examinations revealed no apparent differences between two …