Syndecan-4 and focal adhesion function
A Woods, JR Couchman - Current opinion in cell biology, 2001 - Elsevier
A Woods, JR Couchman
Current opinion in cell biology, 2001•ElsevierTwo groups have now reported the viability of mice that lack syndecan-4. These mice have
wound healing/angiogenesis problems, and fibroblasts from these animals differ in
adhesion and migration from normal. This is consistent with recent in vitro data indicating a
need for signaling via syndecan-4 for focal adhesion formation, and reports that
overexpression of proteins that bind syndecan-4 can modify cell adhesion and migration.
wound healing/angiogenesis problems, and fibroblasts from these animals differ in
adhesion and migration from normal. This is consistent with recent in vitro data indicating a
need for signaling via syndecan-4 for focal adhesion formation, and reports that
overexpression of proteins that bind syndecan-4 can modify cell adhesion and migration.
Two groups have now reported the viability of mice that lack syndecan-4. These mice have wound healing/angiogenesis problems, and fibroblasts from these animals differ in adhesion and migration from normal. This is consistent with recent in vitro data indicating a need for signaling via syndecan-4 for focal adhesion formation, and reports that overexpression of proteins that bind syndecan-4 can modify cell adhesion and migration.
Elsevier