[HTML][HTML] The early course of kidney allograft rejection: defining the time when rejection begins
We studied the early events in mouse kidney allografts and isografts to define when
allorecognition begins and when alloimmune tissue injury begins. Allografts but not isografts
showed T-cell infiltration in perivascular areas from day 1, but tubulitis and arteritis did not
develop until day 7. Flow cytometry confirmed the early allospecific CD3+ CD8+ T-cell
infiltrate. At day 1, both allografts and isografts showed extensive transcriptome changes,
reflecting the response to surgery, but only allografts showed expression of interferon …
allorecognition begins and when alloimmune tissue injury begins. Allografts but not isografts
showed T-cell infiltration in perivascular areas from day 1, but tubulitis and arteritis did not
develop until day 7. Flow cytometry confirmed the early allospecific CD3+ CD8+ T-cell
infiltrate. At day 1, both allografts and isografts showed extensive transcriptome changes,
reflecting the response to surgery, but only allografts showed expression of interferon …