[HTML][HTML] Hypoxia response and VEGF-A expression in human proximal tubular epithelial cells in stable and progressive renal disease
M Rudnicki, P Perco, J Enrich, S Eder, D Heininger… - Laboratory …, 2009 - Elsevier
Proteinuria, inflammation, chronic hypoxia, and rarefaction of peritubular capillaries
contribute to the progression of renal disease by affecting proximal tubular epithelial cells
(PTECs). To study the transcriptional response that separates patients with a stable course
from those with a progressive course of disease, we isolated PTECs by laser capture
microdissection from cryocut tissue sections of patients with proteinuric glomerulopathies
(stable n= 20, progressive n= 11) with a median clinical follow-up of 26 months. Gene …
contribute to the progression of renal disease by affecting proximal tubular epithelial cells
(PTECs). To study the transcriptional response that separates patients with a stable course
from those with a progressive course of disease, we isolated PTECs by laser capture
microdissection from cryocut tissue sections of patients with proteinuric glomerulopathies
(stable n= 20, progressive n= 11) with a median clinical follow-up of 26 months. Gene …