[HTML][HTML] Expression of the adaptor protein Lnk in leukemia cells
S Gery, S Gueller, V Nowak, J Sohn, WK Hofmann… - Experimental …, 2009 - Elsevier
OBJECTIVE: Tyrosine kinases are involved in cytokine signaling and are frequently
aberrantly activated in hematological malignancies. Lnk, a negative regulator of cytokine
signaling, plays critical nonredundant roles in hematopoiesis. By binding to phosphorylated
tyrosine kinases, Lnk inhibits major cytokine receptor signaling, including c-KIT;
erythropoietin receptor− Janus kinase 2 (JAK2); and MPL-JAK2. In the present study, we
investigated Lnk expression and possible function in transformed hematopoietic cells …
aberrantly activated in hematological malignancies. Lnk, a negative regulator of cytokine
signaling, plays critical nonredundant roles in hematopoiesis. By binding to phosphorylated
tyrosine kinases, Lnk inhibits major cytokine receptor signaling, including c-KIT;
erythropoietin receptor− Janus kinase 2 (JAK2); and MPL-JAK2. In the present study, we
investigated Lnk expression and possible function in transformed hematopoietic cells …