[HTML][HTML] Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions: its stabilization by hypoxia …
S Salceda, J Caro - Journal of Biological Chemistry, 1997 - ASBMB
The hypoxia-inducible factor 1 transcriptional activator complex (HIF-1) is involved in the
activation of the erythropoietin and several other hypoxia-responsive genes. The HIF-1
complex is composed of two protein subunits: HIF-1β/ARNT (aryl hydrocarbon receptor
nuclear translocator), which is constitutively expressed, and HIF-1α, which is not present in
normal cells but induced under hypoxic conditions. The HIF-1α subunit is continuously
synthesized and degraded under normoxic conditions, while it accumulates rapidly following …
activation of the erythropoietin and several other hypoxia-responsive genes. The HIF-1
complex is composed of two protein subunits: HIF-1β/ARNT (aryl hydrocarbon receptor
nuclear translocator), which is constitutively expressed, and HIF-1α, which is not present in
normal cells but induced under hypoxic conditions. The HIF-1α subunit is continuously
synthesized and degraded under normoxic conditions, while it accumulates rapidly following …