[HTML][HTML] HIF-1 and HIF-2: working alone or together in hypoxia?

PJ Ratcliffe - The Journal of clinical investigation, 2007 - Am Soc Clin Investig
PJ Ratcliffe
The Journal of clinical investigation, 2007Am Soc Clin Investig
Erythropoietin (EPO) is the hormonal regulator of red cell production and provided the
paradigm for oxygen-regulated gene expression that led to the discovery of hypoxia-
inducible factor (HIF). In this issue of the JCI, Rankin and colleagues show, using targeted
gene inactivation, that induction of Epo expression in murine liver is dependent on the
integrity of HIF-2α, and not HIF-1α (see the related article beginning on page 1068). These
results demonstrate distinct functions for different HIF-α isoforms that could potentially be …
Erythropoietin (EPO) is the hormonal regulator of red cell production and provided the paradigm for oxygen-regulated gene expression that led to the discovery of hypoxia-inducible factor (HIF). In this issue of the JCI, Rankin and colleagues show, using targeted gene inactivation, that induction of Epo expression in murine liver is dependent on the integrity of HIF-2α, and not HIF-1α (see the related article beginning on page 1068). These results demonstrate distinct functions for different HIF-α isoforms that could potentially be exploited in therapeutic approaches to anemia.
The Journal of Clinical Investigation